The resulting impact:
- Decreased efficiency of coupling phosphorylation to the oxidations of the Krebs Cycle
- Greater heat production (thermogenesis)
- Decreased efficiency of food utilization for fat synthesis
® efficacy is supported by two randomized, double-blinded, placebo-controlled (“RDBPC”) weight loss clinical trials.The first study indicated that 7-Keto
® increased weight loss over an eight-week period by 200% more than placebo.
A second trial confirmed these results. The second trial, also RDBPC, confirmed that weight loss over an eight-week period could be increased by a factor of three times7. Importantly, each of these studies confirmed that majority of the weight lost was body fat. Each study controlled for diet, exercise and diuresis effects, and both have been published in international peer reviewed journals.
Results of an additional human clinical study reveal that administration of 7-Keto
® to overweight adults in conjunction with a calorie restricted diet will effectively reverse the decline in resting metabolic rate normally associated with dieting. In this study, a cross-over design in which each participant served as his or her own control, 7-Keto
® plus a restricted calorie diet demonstrated an increase in resting metabolic rate by 1.4% above baseline levels versus a 3.9% decrease in resting metabolic rate in the restricted calorie diet only group. Therefore, the addition of a 7-Keto
® to a restricted calorie diet produced a statistically significant 5.4% increase in daily resting metabolic rate when compared to a calorie-restricted diet alone8
Since introduction as a dietary ingredient in 1998, 7-Keto
® has been the subject of study in 10 well-controlled human clinical studies, including a Phase I safety assessment conducted at the Chicago Center for Clinical Research. Each of these studies monitored laboratory values and adverse events. In all studies, in addition to nearly 1 billion daily doses in sales, no serious adverse events have been attributed to the ingestion of 7-Keto